Police help Pikangikum youth build safer community

first_imgWillow FiddlerAPTN NewsOntario Provincial Police Sgt. Chris Amell is spending his Saturday morning knocking on doors in Pikangikum First Nation.“I’m here for your granddaughters,” he tells one person who answers.Having the police come to your door isn’t always good news.But Amell is not driving a police cruiser nor is he taking anyone to jail.In fact, he’s hoping to prevent that from happening – by picking up youth participants who need a ride to an event coordinated by Project Journey.“From a policing perspective although it’s not answering calls for service, it’s an investment so that we don’t have to answer calls for service,” he says.Amell has worked in Pikangikum since 2007.He’s been running Project Journey since it started in 2013.“A response to a lot of the tragedies that were occurring back in 2007 to 2009, there was a high rate of suicide and the police felt we were in a position to do more in terms of supporting the community to help overcome some of those challenges,” Amell tells APTN News.“When they’re given the opportunities to make healthy choices they… make healthy choices”The five-year project funded by Public Safety aims to reduce youth crime and solvent abuse in the remote First Nation. The program, delivered by the Ontario Provincial Police, is scheduled to end this year.Amell says Project Journey provides positive alternatives for the youth — who make up a large portion of the community.“When they’re given the opportunities to make healthy choices they almost 100 per cent of the time choose to make healthy choices,” he says.Pikangikum is about 500 km northwest of Thunder Bay and is only accessible by plane and boat.The community has a population of about 2,400 — and 97 per cent of the community speaks fluent Anishinaabemowin or Ojibway – and is the first language there.Pikangikum has struggled with social issues like suicides and addiction.“It gives the youth a lot of opportunities and more experiences in life”The chief coroner conducted a review after 16 suicides occurred between 2006 – 2008. All of them were children and youth between 10-19 years old.Tyra King is used to Amell knocking on her door now.“Yeah, it happens a lot,” she says laughing.The 16-year old got involved with Project Journey when it first started.“It gives the youth a lot of opportunities and more experiences in life,” King says.King is participating in a girls’ retreat at the school when APTN meets her. It’s one of the many positive experiences she’s had through regular participation with Project Journey.“I have my hair styling certification, I met Justin Trudeau, traveled a lot and went to conferences,” King says.She said it’s important to have these opportunities.“I faced a lot of alcoholism in my life and I, and the youth face that too a lot of times and a lot of losses of their loved ones. It affects them emotionally, physically and mentally,” says King.Amell says removing barriers that prevent participation is an essential part of the program’s success.“Whether it’s a pair of boots to do winter activities, whether it’s outdoor gear to go canoeing,” he says.“Just making sure they have everything they need so the only choice they really have to make is whether or not to participate.”Cst. Clayton Kenny is with the Pikangikum Police and has worked in the community for two years.On the day APTN meets him, he’s off-duty and helping a group of kids prepare for a canoe trip. It will be the second one he’s been on with Project Journey.“I’ve worked in a number of communities where this is actually the first time I’ve been able to do a program like this and work with the youth,” says Kenny.He believes land-based activities can empower youth.“As First Nations people they are part of the land,” he says.“They’re allowed to be themselves when they’re on the land and realize that they do have something to offer, some skills that they can excel in.”Rusty Keeper is the Youth Outreach Worker for Project Journey. He’s also planning to paddle along on the canoe trip.He knows the challenges that kids face in Pikangikum.“The youth were easily influenced to go start sniffing early. There was a lot of it growing up,” Keeper says.“I mostly stayed away from it but I saw a lot of other kids get turned, you know.”Keeper has also seen the impacts Project Journey has had on the youth.“I think it’s good for it to be here you know, so the kids can have someone to go to, you know to talk to someone.”“We’re seeing a reduction in youth crime, we’re seeing a reduction in solvent abuse”(Young people in Pikangikum take an interest in Willow’s camera during an interview) What will happen to Project Journey at the end of this year is still being worked out, according to Amell.Project Journey has developed partnerships with the community’s health and education authority organizations to possibly take over programming in the community.But one thing is clear.“We’re seeing a reduction in youth crime, we’re seeing a reduction in solvent abuse,” says Amell.And that’s not all.“We’re also seeing an increase in positive relationships between peers, between participants and their families, between participants and the community in general,” he says.Kenny says those connections are key to a safer community.“It’s very important to keep forming positive relationships especially with police because we do work for them and we do need those positive relationships to continue.”For King, who wants to be a makeup artist, Project Journey has opened her eyes to the possibilities ahead.“It gave me a lot of confidence in myself and it gave me a voice and it gave me opportunities and I’m very grateful to have it in my life,” she said.wfiddler@aptn.ca@willowblasizzolast_img read more

Thai diplomat chosen as next head of UN Human Rights Council

Sihasak Phuangketkeow becomes the fifth president of the 47-member Council, which replaced the earlier UN Commission on Human Rights that was scrapped amid concerns about its effectiveness. He was the candidate of the panel’s Asian members.Mr. Phuangketkeow told the Council today in Geneva that he wanted to concentrate over the next year on how members can use their “rich diversity” to forge a more united agenda on key human rights issues.Council members “need to draw synergy from such diversity, recognizing that human rights are indeed universal, indivisible and interdependent, and recognizing… that we all share a common stake in the credibility and effectiveness of the Council as a whole,” he said.Mr. Phuangketkeow succeeds Alex van Meeuwen of Belgium as the Council’s President.Meanwhile, on Friday the Council appointed several new special rapporteurs who will focus on monitoring human rights as they relate to certain issues or countries.Christof Heyns becomes the Special Rapporteur on extrajudicial, summary or arbitrary executions, succeeding Philip Alston; Heiner Bielefeldt replaces Asma Jahangir as the Special Rapporteur on freedom of religion or belief; and Kishore Singh takes over from Vernor Muñoz Villalobos as the Special Rapporteur on the right to education.Calin Georgescu is now Special Rapporteur on the adverse effects of the movement and dumping of toxic and dangerous products and wastes on the enjoyment of human rights, succeeding Okechukwu Ibeanu; Fatsah Ouguergouz replaces Akich Okola as the Independent Expert on the situation of human rights in Burundi; and Marzuki Darusman is the new Special Rapporteur on the situation of human rights in the Democratic People’s Republic of Korea (DPRK), taking over from Vitit Muntarbhorn.Special Rapporteurs and Independent Experts report to the Human Rights Council and serve in both an independent and unpaid capacity. 21 June 2010Thailand’s Ambassador to the United Nations Office in Geneva was today named as the newest President of the UN Human Rights Council, the panel established in 2006 to tackle human rights violations worldwide. read more

Sri Lanka needs space to recover

Referring to the Commonwealth which is headquartered in London, Prof Peiris said it must be remembered that this is a voluntary organisation of 54 member-states with diverse cultures, ethnicities and value systems and that it cannot be a monolith.“If a few member-states attempt to turn such an organisation into a political tool in pursuit of their own agendas, it would not only damage the ethos that the Commonwealth represents but also threaten the very future of the organization,” he said. “These challenges cannot be answered and resolved overnight. They take time and a nation needs space to do so. Sri Lanka is urging that it be given the time and space,” the minister said. Destroyed infrastructure had to be rebuilt and the government invested enormous funds to resuscitate the economy of the war- ravaged areas so that the people would have a means of livelihood for them and their families, the Minister said. (Colombo Gazette) He also said that Sri Lanka is ready and willing to work with the international community to achieve these ends but it cannot be achieved if its efforts at peaceful resolution of its problems are met with constant vilification and castigation by a few in the international community. The Minister stressed that no other country that has emerged from years of internecine strife and terrorism has achieved what Sri Lanka has done in such a short time.He said that the country faced tremendous multiple challenges. Among these challenges was to provide food, shelter and medicines for nearly 300,000 persons displaced from the conflict areas. There were thousands of ex-combatants who had to be rehabilitated and returned to society. There were child soldiers of the LTTE who had to be helped and returned to their families.In addition there were hundreds of thousands of mines and other explosive devices that had to de-activated and removed so that displaced persons could return safely to their former homes and the land put to productive use. The government says Sri Lanka needs time to return to normalcy after nearly three decades of  terrorism and secessionist war.A statement by the External Affairs Ministry quoted Minister G.L Peiris as saying that the reconciliation and rehabilitation is a slow process as other countries that have gone through similar experiences will understand and appreciate. read more

OSC concerned about shift away from standard reporting methods CEO

OSC concerned about shift away from standard reporting methods: CEO TORONTO – The head of Ontario’s securities watchdog says its new whistleblower program can play a role in identifying misleading financial disclosures amongst the growing number of Canadian companies that have veered away from standardized reporting methods.OSC chair and CEO Maureen Jensen said she’s “very worried” about companies using non-standard methods — referred to as “non-GAAP measures” — to report earnings.Using customized reporting techniques can sometimes make a company’s financial performance appear rosier than it really is.In some cases, Jensen said the practice can veer into the realm of securities violation, if the reports are misleading in such a way that materially impacts the company’s stock price.“If the disclosure isn’t accurate then how can investors understand what they’re investing in?” she told reporters Tuesday following her speech to the Toronto Region Board of Trade.“As you move further and further away from standardized reporting, investors can understand it less and less.”Jensen said the OSC already has all of the tools it needs to enforce such cases — it’s just a matter of identifying misleading disclosures, something that the whistleblower program can help with.Since its launch in July, the Ontario Securities Commission’s whistleblower program has already garnered more than 30 tips detailing the kinds of securities law violations that the regulator is targeting in its enforcement actions, Jensen said Tuesday.“Some of them are the kinds of tips that we really wanted — serious offences or serious potential offences in areas that we would never be able to find, such as misstatements in accounting and disclosure violations,” she said.“Those are the types of things that we’re looking for, and that’s what is in some of those tips.”Under the program, the securities regulator offers rewards of up to $5 million for tips that lead to successful prosecution of serious securities law violations such as insider trading, accounting tricks and market manipulation.Several components of the OSC’s program were hotly debated during the consultation process, including how much to pay whistleblowers and whether those involved in the wrongdoing should be eligible for a reward.The OSC had originally planned to cap maximum reward payments to $1.5 million, but it raised that after experts suggested that was too little to compensate senior executives who risk losing high-paying jobs and being blacklisted from their industries.In her first keynote speech since taking the helm of the OSC, Jensen also talked about the need to beef up investor protection, reduce the regulatory burden on publicly traded companies and encourage more companies to improve gender diversity on their boards.Jensen highlighted an initiative by the Canadian Securities Administrators, a coalition of provincial securities regulators, to explore the possibility of banning embedded mutual fund fees.She argued that embedded fees encourage financial advisers to choose funds with higher fees, regardless of how well they are performing.The practice, which she deemed “unacceptable,” amounts to advisers putting their own needs ahead of their clients.The CSA will be publishing a consultation paper at the end of the year that will set out the possible impacts of prohibiting the use of embedded fees in mutual funds. Britain and Australia have banned the fees.“We know this would be a major change not only for advisers and firms, but also for investors,” Jensen said.“And so we must be confident that any reforms are appropriate for the Canadian market. That’s why input from all our stakeholders is necessary throughout this process.”Follow @alexposadzki on Twitter. by Alexandra Posadzki, The Canadian Press Posted Sep 27, 2016 11:09 am MDT Last Updated Sep 27, 2016 at 3:00 pm MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email read more

Varsity sports cut at Newark campus

The OSU-Newark branch campus. Credit: Courtesy of OSUFor Chelsea Dobson, a fourth-year in art at Ohio State’s Newark campus, basketball games are a time for the campus to get together and share in one experience of fandom.“The main sport that I feel like gets the most attention is the basketball team. Usually, those are the best crowds,” said Dobson, who works as a student athletic assistant at OSU-Newark. “They will cheer, they yell crazy things when we have the ball and things like that.”But students at OSU-Newark will not get the chance to cheer on their team next year after it was announced on April 10 that varsity sports will no longer be offered beginning in the fall, because of budget reduction initiatives by the school.The school announced the decision as part of an email sent out to faculty and staff that said, as part of the budget planning for fiscal year 2016, the varsity athletic teams will be discontinued, effective June 30.OSU-Newark offers six varsity sports: women’s volleyball, women’s basketball, softball, men’s basketball, baseball and golf. The sports teams compete in the Ohio Regional Campus Conference, which is an “independent sports organization that serves the regional campuses of Ohio,” according to the email.The school’s recreational and intramural sports will continue on campus, the email said.William MacDonald, dean and director of OSU-Newark, said he understands the impact this decision will have on both student-athletes and the general student population.“It certainly will have an impact on them and I have talked to several of them,” he said. “I had a meeting with our student government and students they invited. Several athletes attended and they made a very well-reasoned argument as to how athletics can benefit students.”During the 2014-15 academic year, OSU-Newark had 70 student-athletes involved in the school’s athletic teams, said Holly Mason, director of student life at OSU-Newark.“Depending on the year and student interest, we typically have 70 – 100 student-athletes competing in varsity athletics in the course of an academic year,” Mason said in an email.MacDonald said the decision to cut varsity sports is part of one set of cuts that have been proposed to balance the budgets for both OSU-Newark and the Central Ohio Technical College, which shares the campus.The budget reduction plans are a necessity because of several economic factors related to the cost of tuition, MacDonald added.“Part of the budget that we built this year (was) based on the assumption that we would have a 2 percent tuition increase, but of course, we didn’t increase tuition by 2 percent,” he said. “The university plugged that hole for all units. And so that helped us this year, so looking to next year, that was one-time money that is going to go away, so we have to cover that gap.”In addition to this expense, which MacDonald said is approximately $290,000, another cost the school has to plan for is caused by the fact that fewer students are enrolling at COTC and that enrollment at OSU-Newark is predicted to remain relatively stagnant.“(COTC’s) enrollment has declined a little bit, our share of expenses will increase because our proportion of the student body is going to increase,” he said. “And then we have all of the uncertainty of the subsidies and tuition. We are not expecting growth in enrollment, at least not in the next couple of years. And so we won’t be seeing new revenue there.”MacDonald said the school has taken precautionary measures by reducing the budget so that these impending costs will be covered in the upcoming years. In total, he said, the school is looking to offset approximately $915,000 in possible expenses with cuts.“It’s conservative, but we have to balance the budget, so that is why we are setting that target,” he said.Although he said it is hard to decide what to cut, MacDonald added that he thinks the cuts the school is making are the ones necessary to preserve the services students need the most.“I would argue that right now, there are other things that we have wanted to do, but haven’t been able to do and probably won’t be able to do until we are able to get through this period of budget pressure,” he said. “If we were, let’s say three or four years from now, we had some sort of boost to our revenue, we know there are things that we want to do that we think will improve student success. Things like expanding our first-generation student learning community (or) providing more scholarships.“Those kind of things would all take priority over varsity athletics.”But it is not just athletics that are on the expenditure chopping block for next year. Other budget cuts announced in the Friday email include the restructuring of the Office of Student Life and the Office of Financial Aid, changes in the hours of operation of the Warner Library, the elimination of at least eight univeristy positions and the discontinuation of large-scale food events such as the fall welcome lunch, spring picnic and holiday reception.Dobson said students were surprised and disappointed upon hearing of these expected cuts, especially the elimination of varsity sports.“General student reaction has just been complete shock, especially with the student-athletes,” she said. “We had no idea that it was even up in the air. It was extremely shocking, just because there was no prior knowledge. It makes it even harder and it is really sad, especially because we felt like this coming year was going to be our year for sports.”Mason said discussions and planning are “currently taking place,” and the school is looking into ways to increase options for recreational and intramural sports, as well as other student organizations“Budget cuts are extremely difficult to endure,” she said. “My heart goes out to our student-athletes, our staff – both administrative and coaching and all that have participated in or been an influence to our program.”MacDonald said even though he understands why students are upset, he hopes they will continue to find ways to be involved in the campus community.“I am hoping that they will realize the value of an Ohio State degree and stick with it, even though they won’t have that opportunity to play varsity sports,” he said. “In the scheme of things, of course, we are looking at preserving the things that are most vital to student success. And in the scheme of things, varsity sports are just not that closely connected to the core of our mission.” read more

IMT launches new body design for Dominator III mechanics truck

first_imgIowa Mold Tooling Co Inc (IMT), the Oshkosh Corporation company and manufacturer of service vehicles, truck-mounted cranes, hydraulic loaders and air compressors for mining and other heavy industries, has announced the release of a new Dominator® III mechanics body. The new body design accommodates the IMT model 12000 telescopic crane without a front stabiliser for customers that do not require 100% lift capacity in all load zones.“Since its release, the IMT Dominator III mechanics truck has been serving a unique niche customer with mid-range lifting needs,” said Jim Hasty, IMT General Manager. “Our new body design is the result of listening to our customers’ needs, and demonstrates our unyielding commitment to providing reliable and durable products that help them get their work done.” The new Dominator III body will be available in both 11 ft and 14 ft lengths, replacing the existing 13 ft version. With two side pack configurations for each body length — a right front raised with the left side all raised and an all raised version — customers have four configuration options to choose from.The Dominator III model is designed for customers who need more lifting capacity than the Dominator II vehicle’s 10,000 lb maximum, but do not require the 14,000 lb capacity of the Dominator IV mechanics truck. Designed specifically to support the IMT 12000 telescopic crane, which provides up to 30 ft of reach and a Penta Boom™ design. With a flat top that eliminates stress concentrations inherent with certain boom designs and a half hex that controls tracking at long reaches, “the innovative five-sided boom offers premium strength and durability.”Standard features of the IMT 12000 telescopic crane include:• Ten degrees of negative boom angle, providing added versatility and allowing the crane to be reached more easily from ground level• A fully proportional piston grip radio remote control offering traditional fit and operation• LED overload indicator lights on the remote control handle that alert the operator when the crane is approaching overload condition and in overload• A flip sheave boom tip for added lift height in tight quarters• A planetary winch that allows for faster hoisting and lowering speeds and smoother overall operation• Patented boom hook stow that allows the boom hook to be stowed more easily and fasterThe Dominator III model also features excellent accessibility to tools — without losing any storage ¬— by providing front vertical compartments with single doors. IMT also incorporated the patented shelf hanger bracket system that enables quick adjustments of compartment shelves.  In addition, the truck features the new enhancements to the Dominator family:• A energy absorbing boom stow that protects the top of the body compartments from damage if too much pressure is exerted from stowing the crane• High-intensity LED compartment lighting• A multiplex electrical system with programmable logic for increased reliabilityThe new Dominator III mechanic bodies are available for order now and are currently planned to being shipping in December 2015.last_img read more

SFR veut exploiter la 4G à fond

first_imgSFR veut exploiter la 4G à fondLe deuxième opérateur français prépare sa première offre commerciale pour la 4G, pour un lancement en début d’année 2013. Pour autant, la 3G et le WiFi sont pas abandonnés…Est-ce la conséquence du récent débarquement de Franck Esser de son poste de PDG ? Toujours est-il que SFR semble déterminer à lancer sa grande offensive sur le terrain de la 4G, pour un lancement commercial en début d’année 2013. Cela débutera avec le déploiement pilote dans deux villes, Lyon et Montpellier, ainsi qu’à Marseille, déjà priviligiée depuis septembre 2011 et un test terrain réalisé en partenariat avec Nokia Siemens Network, explique IT Espresso. À lire aussiRéseau 4G de SFR : tout sur les forfaits, les lancements et les prixPour autant, le deuxième opérateur français ne compte pas laisser tomber la 3G avec le déploiement de réseaux offrant encore plus de débit. SFR devrait ainsi parvenir à une couverture de 98,5% de la population en 3G+ (norme HSDPA, surf à 3,6 Mbit/s) très bientôt et se concentre sur deux nouveaux objectifs : la généralisation de la technologie HSPA+ (introduite en 2010) offrant un débit crête de 21 Mbit/s et dont l’objectif est de couvrir 88% de la population d’ici la fin 2012, et le déploiement du HSPA+ upgradé à 42 Mbit/s (introduit fin 2011) avec pour objectif 63% de la population couverte avant la fin d’année. En outre, SFR continue de développer son femtocell, un amplificateur 3G à domicile qui en sera à sa troisième génération cet été. Les performances seront doublées avec un débit maximum de 14,4 Mbit/s (contre 7,2 Mbit/s actuellement) et “deux fois plus de communications en simultané” (8 contre 4 actuellement). Enfin, la marque au carré rouge veut faciliter le passage de la 3G au WiFi avec son SFR Auto Connect WiFi, qui permet ce changement “de manière automatique, sans discontinuité ni manipulation”. Pour l’instant réservé aux abonnés disposant d’un téléphone ou d’une tablette Apple, il sera “progressivement lancé sur les autres modèles de terminaux”. Le 30 mars 2012 à 18:45 • Maxime Lambertlast_img read more

Maladie de Huntington symptômes diagnostic tout savoir sur cette maladie

first_imgMaladie de Huntington : symptômes, diagnostic, tout savoir sur cette maladieCette maladie, parfois appelée chorée de Huntington est une maladie héréditaire et orpheline. Très rare en France, elle se traduit par des troubles psychiatriques et moteurs. Maxisciences vous en dit plusLa maladie de Huntington touche les personnes âgées de 40 à 50 ans et peut plus rarement se manifester sous une forme précoce entre 15 et 25 ans. En France, on retrouve cette maladie chez 5 à 7 personnes pour 100000. 18000 personnes sont concernés dont 12000 encore sans symptômes sont recensés en France selon l’Institut national de la santé et de la recherche médicale (Inserm).  SymptômesLes symptômes sont très différents, d’un individu à l’autre et il faut en moyenne une vingtaine d’années pour que les symptômesmoteurs atteignent le stade le plus avancé. Il existe différents symptômes :Les symptômes cognitifs  Les symptômes cognitifs peuvent être difficiles à diagnostiquer car ils débutent en général de manière progressive. Ils ne se développent pas forcément en même temps que les troubles moteurs. La maladie de Huntington provoque, à long terme, une démence sous-corticale : qui touche la substance blanche, les ganglions de la base, le thalamus et hypothalamus. On peut constater des troubles de la mémoire, un ralentissement de la pensée et des troubles de l’attention.Les symptômes moteursLes malades souffrant de la maladie de Huntington peuvent être atteints de chorée. La chorée est caractérisée par des mouvement incontrôlés et involontaires. Il peuvent affecter toutes les parties du corps mais se calme durant le sommeil. La parole devient hésitante, le patient peut tirer la langue. La survenue de ce trouble peut entraîner des difficultés à se déplacer. Troubles psychiatriques Les troubles psychiatriques sont extrêmement différents d’un patient à l’autre. La dépression, l’anxiété et l’irritabilité ainsi que l’apathie sont les premiers symptômes. Des troubles du sommeil peuvent aussi intervenir. TransmissionÀ lire aussiDengue : symptômes, traitement, prévention, où en est-on ?La maladie de Huntington est une maladie génétique et héréditaire. Sa transmission est autosomiquedominante, ce qui signifie que les personnes saines ne transmettent pas la maladie, la probabilité pour qu’une personne atteinte transmette le gène est de 50%. DiagnosticLe diagnostic de la maladie de Huntington repose à la fois sur des observations cliniques sur les troubles caractéristiques de la maladie et sur un test génétique. Une analyse du gène de la huntingtine à partir d’un prélèvement sanguin permet de confirmer le diagnostic. Le 5 février 2018 à 13:13 • Morsli Paulinelast_img read more

Brock Lesnar vs Goldberg made official for the WWE Survivor Series PPV

first_img Now Playing Up Next Pinterest Is The Rocks Return To WWE In Jeopardy? Twitter Will Bobby Lashley Finally Face Brock Lesnar? Which Wrestler Is Next To Be Inducted Into The WWE Hall Of Fame? Now Playing Up Next Hope it doesn’t turn out as a rehash of Wrestlemania 20 Now Playing Up Next WWE.com announced on Tuesday that Brock Lesnar will face Goldberg at the WWE Survivor Series PPV on November 20 live from the Air Canada Centre in Toronto.This match had been setup over the last few weeks on WWE television with the release of the WWE 2K17 video game, a challenge issued by Paul Heyman on behalf of Lesnar and Goldberg’s acceptance of the challenge last week on RAW.BREAKING NEWS: @Goldberg will face @BrockLesnar at @WWE #SurvivorSeries Sunday, Nov. 20 on @WWENetwork! pic.twitter.com/P6olKFG7iT— WWE (@WWE) October 25, 2016 Videos Articles Recommended videosPowered by AnyClipWill Bobby Lashley Finally Face Brock Lesnar?Video Player is loading.Play VideoPauseUnmuteDuration 0:31/Current Time 0:04Loaded: 100.00%0:05Remaining Time -0:27 FullscreenUp NextThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Replay the list Brock Lesnar WWE Smackdown Live Preview: Reigns vs. Murphy, Randy Orton responds to Kofi Kingston Now Playing Up Next Facebook Brock Lesnar Takes WWE Universal Championshipcenter_img Videos Articles Braun Strowman Still Not Cleared For Match WhatsApp WWE Smackdown Results – 8/13/19 (Reigns vs. Murphy, Randy Orton responds to Kofi Kingston) 1 COMMENT Google+ Now Playing Up Next Mayurnath Reve Jason Namako RELATED ARTICLESMORE FROM AUTHOR Bobby Lashley Videos Articles WWE NXT Results – 8/14/19 (NXT Breakout Tournament Finals, Breezango/Forgotten Sons) October 26, 2016 at 1:07 am Paul Heyman Comments are closed.last_img read more

1 dead at Miami Gardens gas station shooting

first_imgMIAMI GARDENS, FLA. (WSVN) – One person is dead after a shooting at a Miami Gardens gas station, Saturday.Officials said a man was inside the Exxon near Northwest 27th Avenue and the Palmetto Expressway, when someone walked inside and shot him in the head.The subject then fled on foot.If you have any information on this shooting, call Miami-Dade Crime Stoppers at 305-471-TIPS. Remember, you can always remain anonymous, and you may be eligible for a $3,000 reward.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.last_img

VW enters the carsharing game with allelectric WeShare launch in Berlin

first_imgEnlarge ImageThe e-Golf fleet is mighty cool, but its appeal should expand further once the ID 3 joins the WeShare family. Volkswagen Volkswagen has talked a big game about the future of mobility, but when it comes to nascent schemes like car sharing, it hasn’t really rolled out much. BMW and Daimler, on the other hand, are throwing down more than $1 billion to combine their efforts into a five-joint-venture Mobility Megazord. So what is Volkswagen to do? Well, it had better start playing catch-up, which it appears to be doing.VW announced on Thursday that it is entering the car-sharing market with WeShare. Starting in Berlin, WeShare will only offer electric vehicles to people, going a bit above and beyond the average car-sharing service, which tends to have a mix of vehicle types available. It’s starting with a fleet of 1,500 e-Golf compact hatchbacks, and in the future, it will add 500 e-Up! subcompact hatchbacks. Then, after VW’s upcoming ID 3 EV comes online, that will join the fleet, as well. In 2020, WeShare will expand to both Prague and Hamburg.For now, the service is limited to a 150-square-kilometer (roughly 58-square-mile) chunk of the Berlin area, focusing on the city center and expanding beyond the city’s ring train line. People looking to use the service need to have both a phone and a credit card, they must be at least 21 years old, they must be licensed for over a year and they need a permanent address in Germany. WeShare will cost 0.19 euro (about $0.22) per minute to start, but in September, it’ll expand to three different pricing tiers averaging about 0.29 euro (about $0.33) per minute. Registration fees and airport fees will be waived.Since the vehicles are electric, they’ll need to be charged, which will happen on public chargers. To that end, WeShare is working with two grocery chains, Lidl and Kaufland, to add public charging points at over 70 locations for easier access to electrons. WeShare employees will collect and charge vehicles with low batteries, but eventually, VW wants to add incentives for people who charge cars themselves.While VW might be behind in car-sharing compared to BMW and Daimler, that’s not to say Volkswagen isn’t exploring future mobility ideas in other ways. In May, VW launched its Inclusive Mobility initiative, which aims to ensure future methods of transportation are built with all groups in mind. The company is also working to test robotaxis and other services in China in the near future. And then there’s Moia, the VW Group brand dedicated to ride-hailing, which spawned an electric van concept with loads of space for up to six passengers. 2019 Volkswagen Arteon: Meet VW’s new stylish flagship Volkswagen Now playing: Watch this: Post a comment 2020 BMW M340i review: A dash of M makes everything better 2019 VW Golf GTI Rabbit review: The best daily driver gets better Volkswagen Preview • 2019 Volkswagen Arteon first drive: Flagship fastback feels familiar Tags 0 Carpool in antisocial silence with VW’s Moia ride-hailing concept Review • 2019 Volkswagen Arteon review: VW’s CC followup is more than just a carbon copy News • 2019 Volkswagen Arteon is pricey, starting from $36,840 Car Industry 2020 Kia Soul EV first drive: More style, more range, more fun Share your voice More about 2019 Volkswagen Arteon 10 Photos More From Roadshow 4:18last_img read more

IHCL Tata Steel prepare for EGMs to remove Cyrus Mistry Nusli Wadia

first_imgThe Taj Mahal hotel is seen in Mumbai December 14, 2008. Indian Hotels Company Limited (IHCL), which owns the Taj chain of hotels, will hold an extraordinary general meeting (EGM) on December 20 to pass resolutions for Cyrus Mistry’s removal from the company’s board.Reuters fileThe next week will be crucial for Tata Group companies in view of the EGMs that have been called to remove Cyrus Mistry from these companies.Indian Hotels Company Limited (IHCL), the owner of Taj chain of hotels, has called for the EGM on December 20, 2016.”We now seek your support of the resolution that Tata Sons has moved in the forthcoming Extraordinary General Meetings (EGM) of our companies, for the removal of Cyrus Mistry as Director…As a long-standing partner in the Tata Group companies, we seek your support of the EGM resolutions to enable our companies to continue on the path of growth and value creation, as they have done over their long-standing past history,” Ratan Tata said in a statement addressed to the shareholders of IHCL.E-voting for IHCL resolution”The e-voting period commences on December 15, 2016 (9:00 am) and ends on December 19, 2016 (5:00 pm)and thee-voting module shall be disabled by NSDL for voting thereafter. During this period Members of the Company, holding shares either in physical form or in dematerialized form, as on the cut-off date i.e. December 13, 2016 may cast their vote electronically. Once the vote on a resolution is cast by the Member, he/she shall not be allowed to change it subsequently or cast the vote again,” read the notice to shareholders.”If you are already registered with NSDL for remote e-voting then you can use existing user ID and password for casting your vote or obtain the login ID and password by sending a request at evoting@nsdl.co.in or investorrelations@tajhotels.com,” according to the notice.The procedure to login to e-Voting website is given below:Open the attached PDF file “e-Voting.pdf” giving your Client ID (in case you are holding shares in demat mode) or Folio No. (in case you are holding shares in physical mode) as password, which contains your “User ID” and “Password for e-voting”. Please note that the password is an initial password. You will not receive this PDF file if you are already registered with NSDL for e-voting.Launch internet browser by typing the URL https://www.evoting.nsdl.com/Click on “Shareholder – Login”.Put User ID and password as initial password noted in step (1) above and Click Login. If you are already registered with NSDL for e-voting then you can use your existing user ID and password. If you forgot your password, you can reset your password by using “Forgot User Details/Password” option available on www.evoting.nsdl.comPassword Change Menu appears. Change the password with new password of your choice with minimum 8 digits/characters or combination thereof.Home page of remote “e-Voting” opens. Click on e-Voting: Active Voting Cycles.Select “EVEN” of The Indian Hotels Company Limited. Members can cast their vote online from December 15, 2016 (9:00 am) till December 19, 2016 (5:00 pm).Note: e-Voting shall not be allowed beyond said time.Now you are ready for “e-Voting” as “Cast Vote” page opens.Cast your vote by selecting appropriate option and click on “Submit” and also “Confirm”, when prompted.Institutional shareholders (i.e., other than Individuals, HUF, NRI etc.) are also required to send scanned copy (PDF/JPG Format) of the relevant Board Resolution/Authority Letter etc. together with attested specimen signature of the duly authorized signatory(ies) who are authorized to vote, to the Scrutinizer through e-mail fraternitygroup2010@gmail.com with a copy marked toevoting@nsdl.co.in.Further, NSDL is pleased to inform you that NSDL has now integrated its e-Services website (https://eservices.nsdl.com/) with the aforesaid e-Voting system of NSDL, which enables you as a registered User of IDeAS facility to also access e-Voting system of NSDL for casting your votes by using your existing login credentials viz.; User ID and password of IDeAS facility. Thus, you would not be required to log-in to e-Voting system separately for casting votes in respect of the resolutions of companies.Tata Steel EGMTata Steel will be holding its extraordinary general meeting (EGM) on December 21 to seek shareholder nod for the removal of Cyrus Mistry and Nusli Wadia as directors of the company.E-voting for Tata Steel resolution”The remote e-voting period commences on Sunday, December 18, 2016 at 9.00 a.m. IST and ends on Tuesday, December 20, 2016 at 5.00 p.m. IST. During this period, Members may cast their vote electronically. Please note that the voting rights will be on the basis of shareholding as on the cut-off date, i.e. Wednesday, December 14, 2016. Any person, who is a Member of the Company as on the cut-off date is eligible to cast vote on all the resolutions set forth in the Notice of EGM,” the EGM notice for Tata Steel shareholders read.The instructions and other information for remote e-voting are: 1. Open PDF file namely “TSL remote e-voting.pdf” with your Client ID or Folio No. as password. The said PDF file contains your user ID and password/PIN for remote e-voting. Please note that the password is an initial password. You will not receive this PDF file if you are already registered with NSDL for e-voting. 2. Open the internet browser and type the following URL: https://www.evoting.nsdl.com/ 3. Click on Shareholder – Login. 4. If you are already registered with NSDL for remote e-voting then you can use your existing user ID and password/PIN for casting your vote. If you forgot your password, you can reset your password by using “Forgot User Details/Password” option available on www.evoting.nsdl.com 5. If you are logging-in for the first time, please enter the user ID and password provided in the PDF file attached with this e-mail as initial password. Click Login. 6. The Password Change Menu will appear on your screen. Change the password/PIN with new password of your choice, making sure that it contains a minimum of 8 digits or characters or a combination of both. Please take utmost care to keep your password confidential. 7. Once the remote e-voting home page opens, click on remote e-voting > Active e-Voting Cycles. 8. Select “EVEN” (E-Voting Event Number) of Tata Steel Limited which is 105772. Now you are ready for remote e-voting as Cast Vote page opens. 9. Cast your vote by selecting appropriate option and click on “Submit” and also “Confirm” when prompted. 10. Upon confirmation, the message “Vote cast successfully” will be displayed. 11. Once the vote on the resolution is cast, the Member shall not be allowed to change it subsequently. 12. Institutional shareholders (i.e., other than individuals, HUF, NRI, etc.) are required to send scanned copy (PDF/JPG format) of the relevant Board Resolution/Authority letter, etc., together with attested specimen signature of the duly authorised signatory(ies) who are authorised to vote, to the Scrutinizer through e-mail to tsl.scrutinizer@gmail.com, with a copy marked to evoting@nsdl.co.in.Tata Steel shares closed at Rs 414 on Friday on the BSE while IHCL ended at Rs 99. Tata Sons holds 28.01 percent in IHCL and 29.75 percent in Tata Steel. A general view shows the Tata Steel works in Scunthorpe, northern England, October 27, 2015. Tata Steel is the biggest steelmaker in Britain.Reuters filelast_img read more

Legislative Black Caucus Hosts Town Hall Meeting

first_imgLawmakers from Baltimore and surrounding counties who attended the final Town Hall sponsored by the Maryland Legislative Black Caucus (LBC) were still reeling from U.S. District Court Judge James K. Bredar’s recent decision to ignore the preference of the Baltimore community members by instead appointing a “combined team” of individuals to serve as the independent monitor for Baltimore’s consent decree with the federal department of justice.  State Sen. Joan Carter Conway said the lawmakers are weighing their options and deciding how best to intervene.     “The Caucus will monitor this issue and make it one of our priorities,” said Del. Curt Anderson, chair of the Baltimore City Delegation (Baltimore-43). “A federal judge doesn’t have that ability [to appoint a team] not being representative of the people of Baltimore,” Anderson said to the room of 200 city and county residents.  With respect to other LBC priorities, Del. Cheryl Glenn (Baltimore-45), LBC chair, said she has made it clear to Attorney General Brian Frosh that the HBCU equity trial must run its course when Judge Catherine E. Blake makes her final ruling in the remedial phase of the trial, expected at any time. “We’ve spoken to the Attorney General’s Office and let them know that we want this case settled. We will not tolerate an appeal of this case,” Glenn said.  Glenn said the LBC stands ready to intervene if the state makes any movement toward appealing the final outcome of the 10-year-old lawsuit brought by alumni, students and supporters of Maryland’s four HBCU’s that alleges widespread continuing discrimination in the state’s higher education system. The LBC reported on the group’s leadership in passing legislation during the 2017 session to protect Maryland residents against prescription price gouging. Del. Mary Washington (Baltimore-43) reported on the legislation preventing suspension and expulsion of young children from public schools passed in March 2017.  “It wasn’t easy, but we had to draw a line when it came to suspending our youngest children,” Washington said. Anderson said bail reform is still on the table for the 2018 session and admitted the LBC was not united in their views on eliminating excessive bail for minor offenses. “It was a rather contentious issue that we tried to resolve this legislative session,” he said.Glenn vowed that the General Assembly would act in early 2018 on her legislation to ensure minority participation in the state’s nascent cannabis industry. “We’re asking that this legislation become Senate Bill 1 and House Bill 1 and that this legislation will be passed as emergency legislation at the beginning of the session,” she said. “You will know.”last_img read more

Silver Pixel Awards Honor Digital Marketings Finest

first_imgOver 300 from the entertainment industry’s digital-marketing community gathered Thursday to celebrate some of its best and brightest at Snapchat’s Venice offices.For the fourth annual Silver Pixel Awards, which honor the pioneers of the field, three different awards were handed out for the first time by Hollywood in Pixels, a non-profit organization that saves and protects digital marketing film campaigns from deletion and celebrates those campaigns as a part of Hollywood’s history.Accepting the first-ever Vanguard award, Anthy Price, EVP of Media Integrated Marketing and Synergy at Walt Disney Studios, recalled how she lobbied hard in the late 1990s for the first pop-up ads devoted to promoting movies while still at Universal Pictures.“I remember when I was desperate to get ads on AOL Instant Messenger because my daughter was on it all the time,” said Price, who worked on titles ranging from “Schindler’s List” to “Black Panther” over a 35-year career. “It was the Wild Wild West back then. We’ve come so far.” ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15 Popular on Variety center_img Also accepting top honors on the night was Silver Pixel winner Amy Elkins, EVP, media & marketing innovation for STX Entertainment, and Sarah Pollok, VP of digital media at Warner Bros received the first-ever “Rising Pixel” honor.Bettina Sherick (pictured above), founder and president of Hollywood in Pixels, opened the evening with a moving speech including a pledge to have her organization do more to help talented associates from underrepresented communities get a leg up in the business.“The movie-going audience is becoming going more diverse,” said Sherrick, a veteran digital marketing executive. “It’s good business to have diverse voices in the room.”Variety and Snapchat were presenting sponsors of the fourth annual Silver Pixel Awards.last_img read more

If Youre Not Paying Attention to Korean Pop Music You Should Be

first_imgStay on target If you’re like everyone else on earth, you’ve probably heard Psy’s “Gangnam Style” way too many times. It’s still the single most popular video ever put on YouTube, and it’s a bit odd in the sense that it’s one of the very few turbo-popular songs over the years that hasn’t been in English. For a lot of people, that’s a bit… well… odd… The US and England have largely been the twin fulcra of modern pop-culture, but we’re starting to see that balance of social power shift — to Asia.Korean Pop can be read as a sort of canary in the coal mine. Granted, nothing since Gangnam style has shared nearly the same ubiquity, but that doesn’t mean the Korean Pop Music industry isn’t growing.In the US, K-Pop has enjoyed some success, but it’s never really moved beyond a handful of mega-fans (like yours truly). Elsewhere in the world, though, it’s fighting and in many cases winning the battle for prominence. Africa, Asia, and most of Latin America harbor huge fanbases for Korea’s latest cultural export, and that’s not by accident.via kpop-all.comThe government of South Korean has been pushing their music as a roundabout means of bolstering their growing trade empire — and yeah, I’m serious. Government subsidies and extensive support at every level have more than quadrupled the total value of Korea’s exports. By whetting the appetite of other markets for Korean apparel, food, and culture in a broad sense, South Korea’s been able to secure a planet’s worth of fans. And in the era of globalization, that’s a huge boon for a small nation with no natural, friendly neighbors.In much the same way that American cinema has been guided heavily by foreign markets so has this phenomenon. If you’re curious, check this out which digs into the complex relationship between China and Hollywood. Many stateside producers and rappers like Kanye and Snoop Dogg have started making tracks for K-Pop stars. Snoop Dogg’s big contribution was “Hangover,” a collab with Psy. These partnerships help elevate Korean music in the eyes of global audiences. Most people have at least heard of Kanye and Snoop, so for Korean stars looking to legitimize themselves in the eyes of millions, collaborations are a boon.And that alone is interesting isn’t it? K-pop gets branded an emerging global market, Americans, eager to make a few more bucks invest in the market, and in so doing aid the growing dominance of Korean culture.All that said, K-pops real innovation is the fusion of disparate cultural elements. It’s a pastiche, pulling from, obviously, Korean culture, but also European dance, American rap and iconography, and complex dance choreography that channels mid-to-late 90s dance crazes. The effect is a cultural export that’s truly global. In some ways, Korean pop music belongs to people the world over. It focuses on simple, universal themes and infectiously catchy hooks that are easy to slip back into. Big Bang’s “Fantastic Baby” or 2NE1’s “I am the best” are testaments to this.The elements that helped make American bubblegum pop-appealing to the masses have been distilled to their essentials in Korea and reworked and adapted to fit with today’s internet-driven viral culture. In essence, the country’s weaponized its culture and has positioned itself as a new hub of global entertainment. And while that’s been a tremendous boost to Korea’s economy, it’s come with some disconcerting costs.You may have heard about the prevalence of plastic surgery in South Korea, and that’s in part because of their shocking, oppressive beauty standards. The US takes a lot of flak from the global community for its narrow fashion rules, but Korea, along with boiling down the driving beats and memorable hooks of Brittany Spears, concentrated toxic notions of ideal body size and shape.Korean pop stars will get lots of plastic surgery, whiten their skin, and even remove many stereotypically Asian features (namely the epicanthic eye folds). Perhaps worse is the brutal nature of the K-pop idol industry. Aspiring musicians and dancers have to train every day at special schools from a very early age. The training is not only brutal, but it often puts prospective stars into tremendous debt. Training just one pop idol can cost upwards of $3 million, and when you consider that most groups have at least four, often five or more, the problem becomes pretty clear. Not every idol makes it, and a good chunk doesn’t make their money back. Depending upon the contract the idol signed, failure to gain traction with audiences isn’t just a failed dream, it’s a life-ruiner.Despite that, there’s a shocking amount of depth to the genre. Groups like Big Bang have been massive influences on people and music and fashion the world over, and they often address problems endemic to Korean culture, like the country’s prodigious alcohol consumption. It’s hard to say if K-pop’s meteoric rise will continue, or if the industry’s problems will catch up to it. For now, though, we can all sit back and enjoy some of the most interesting pop music around. Even if it’s production is a bit problematic.Next week, we’ll highlight a dozen K-pop groups you should be following so you can get your feet wet. Scientists Discover Perfectly Preserved Dinosaur Skin in Korea11 Cool Korean Shows We Want Netflix to Bring Over last_img read more

Each PS4 sale makes more profit for AMD than Sony but how

first_imgIt’s basically game industry tradition at this point to make a loss on console sales, but make the money back selling software — similar to the free razors Gillette sends you, knowing you’ll continue buying the refills. This time around, Sony is actually only taking a very small loss per each console sold, as it costs $381 to manufacture the hardware, while packaging, shipping, and other factors likely push the total cost per console over the $399 price tag. A portion of that $381 total manufacturing cost is the console’s custom-built AMD processor, which costs $100. That means AMD is making more than Sony on every PS4 sold.Considering Sony is likely making a loss on each console once you factor in packaging, shipping, and advertising costs, AMD would obviously be making more per console sold regardless of the profit margin. However, just because the AMD chip costs $100 doesn’t mean the company is skimming that much off the PS4 sales.AMD has stated in the past that typical margins hover around the 35%-40% range, and that margins on parts similar to the ones used in the PS4 yield a lower number, hovering in the mid-teens. So, the normal range of 35%-40% certainly isn’t $100 to begin with, and a “mid-teens” percentage would only be around $15. If Sony magically expended no extra costs beyond that $381 figure, the difference between Sony and AMD’s PS4 revenue would be negligible. However, due to the likely packaging, shipping, and marketing costs Sony dumps into the PS4, AMD is making more per console than Sony, but not that much more.last_img read more

Genes ex silico Computerdesigned virus yields phenotype expression benefits

first_img Dr. Wadie F. Bahou, MD, in Stony Brook’s Department of Medicine, works with a research group consisting of Varsha Sitaraman and Dmitri V. Gnatenko in the Department of Medicine; Patrick Hearing, Eckard Wimmer and Steffen Mueller in the Molecular Genetics and Microbiology Department; and Steve Skiena and Charles B. Ward in the Computer Sciences Department.“Our group is composed of individuals with long-standing interests in computational biology, virology, and gene therapy using viruses,” says Bahou. Thus, my group has been most interested in modifying genomes as strategies for gene therapy, Eckard and Steffen are pioneers in recoding viruses for vaccine development, while Steve and Charles provide the critical common thread for all our computational studies.”The key step in their achievement was to computationally redesign Rep 78/68 so that it was better tolerated by adenoviral vectors. “Prior research by our team had previously developed a computational algorithm for redesigning genes based on synonymous codon pair recoding,” Bahou notes. “The real leap of faith was to ask whether the algorithm could be applied to the case of viral/viral interactions. The redesign was relatively straightforward using the previously developed computational algorithm.”The methods that the team used to demonstrate that their leap of faith was justified were equally innovative. As Bahou explains, “The real innovation here is progressive evidence that synonymous pair bias actually can be manipulated to change fundamental characteristics of biological functions. Members of our team have previously demonstrated this for poliovirus and influenza virus, and in this case, we have shown its relevance for generating a novel gene therapy adenovirus.”Bahou also sees a number of potential avenues for further developing the group’s line of research. “Certainly the possibility of using these reengineered viral systems for vaccine development is an obvious application. For applications directly related to this most recent manuscript,” he continues, “it provides a unique opportunity for safe methods for long-term gene delivery. On a broader application, one could envision entire cell systems with recoded genes as a means of altering cellular function in general. This is a forward-thinking statement, but certainly predicated on the status of genome synthesis coupled with progressive information on genetic pathways that regulate cell functions.”Those applications, he adds, will most likely feature the ability to rapidly characterize and synthesize attenuated genomes as new vaccines. In addition, “we are currently testing our ability to safely use this technology for gene replacement strategies which have been limited by concerns for insertional mutagenesis” – mutations caused by inserting genes into a genome. “Such an issue is especially relevant for benign diseases such as hemophilia where cellular transformation using integrating lentiviruses should be considered an unacceptable risk for long-term gene replacement strategies. Therefore,” Bahou points out, “our collective group is currently trying to apply this research as a safe means of long-term gene replacement. At the same time, Bahou stresses that “It’s important to note that genome reengineering using synonymous codon pair restructuring is a relatively new concept, and we fully anticipate that the applications will broaden over time. In theory,” he concludes, “we should be able to modify genomes for both attenuated expression and enhanced expression, depending on the situational requirements. In that respect, the technology is relevant for many other biological systems, especially when developing computational approaches to modifying cellular systems at many levels.” Viruses evolve to play by host rules Citation: Genes ex silico: Computer-designed virus yields phenotype expression benefits (2011, August 29) retrieved 18 August 2019 from https://phys.org/news/2011-08-genes-silico-computer-designed-virus-yields.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector, Published online before print August 15, 2011, doi:10.1073/pnas.1102883108 , PNAS August 23, 2011 vol. 108 no. 34, 14294-14299 Functional characterization of single-backbone Ad/AAV/dRep hybrid virus. (A) Schema of Ad/AAV/dRep with predicted monomeric (M) and dimeric (D) forms resulting from productive Rep 78 cleavage of endogenous AAV integrating elements p5IEE and AAV TR (Fig. 2 shows excision model). Sizes are as follows: ψ, Ad packaging sequence (0.4 kb); pCMV/EGFP cassette (1.6 kb); pTK/NeoR, (1.1 kb); Ad, Ad base pairs 3,330 to 3,940 (0.6 kb); p5IEE, 135 bp; AAV TR (145 bp each plus G-C tail); and dRep, approximately 1.9 kb. (B) Ad/AAV/dRep was serially passaged in 293 cells, and at indicated passages (P), Hirt DNA was isolated for genomic analysis using the approximately 0.2-kb Ad left end inverted TR (ITR base pairs 1-194) as probe (horizontal bar). *Parent Ad/AAV/dRep virus. © PHAS, doi: 10.1073/pnas.1102883108 (PhysOrg.com) — Gene therapy is medicine’s rising star with adeno-associated virus (AAV) vectors – nonpathogenic parvoviruses – among the most promising supporting actors, due largely to their capability to integrate into transcriptionally silent genomic regions (areas that do not, via RNA polymerases, make a messenger RNA copy of DNA-stored genetic information). That being said, there’s been a downside in assembling AAV vectors into adenoviral (Ad) viral backbones, which are used extensively in genetic research and therapy: They rely on replication (Rep) proteins – in this study, the Rep 78/68 polypeptide – which limit viral amplification methodologies. Recently, however, researchers at Stony Brook University have used computational microbiology to reengineer the Rep gene through synonymous codon pair recoding, a technique in which the meaning of a codon (a set of three base nucleotides) is changed in a dynamic site- or mRNA-specific way – that is, it competes and shares expression with the standard. The experimental results demonstrate the value synonymous codon pair reengineering can have in modifying endpoint expression. Copyright 2011 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. Explore furtherlast_img read more

More care should be taken while planting trees Experts

first_imgKolkata: City based ecologists feel that the state Forest department, as well as the Parks and Squares department of Kolkata Municipal Corporation, should strictly adhere to some basic theories of urban plantation when they go for planting trees in the city. The observation comes in the wake of nearly 150 trees toppling in the city on Tuesday evening.”Rapid urbanisation in the city is emerging as a bane for the trees. Work for underground sewerage, underground telephone cables and underground electric wires are taking place on a regular basis, which is often destroying the roots of the trees, making them vulnerable to storms and squalls,” feels noted ecologist Nandadulal Parui. Also Read – Heavy rain hits traffic, flightsAccording to Parui, trees that usually follow a lateral growth pattern can withstand greater wind velocity than those that have a vertical growth pattern. “Trees like Bakul, Jarul, Gulmohar and Shirish have a lateral growth pattern. They grow to a medium height and have the capacity to withstand high wind velocity, which trees with vertical growth pattern cannot. In urban areas, taking care of the nature of trees before plantation is of utmost importance. There are trees whose wood is tough enough to withstand the velocity of wind,” he maintained. Also Read – Speeding Jaguar crashes into Merc, 2 B’deshi bystanders killedSoumitra Paul, Assistant Professor of the Botany department of Calcutta University, however, feels that the state Forest department and KMC plants trees in a much more scientific manner than what was done ten-twelve years ago. “Trees are not getting proper space to expand because of rapid urbanisation. The soil is losing its strength to hold the trees, resulting in their felling,” Paul said. He feels that putting concrete, cement or any sort of barrier at the bottom of the tree allows it to absorb rain water or precipitation of similar nature in a better way and is favourable factor for its growth. “If a tree is situated at an upward or sloping level, the water flows downwards and the trees fail to absorb water properly. We should remember that a tree uproots because of problems in its roots that lie below the ground. It has nothing to do with cement or concrete surrounding the tree above the ground,” Paul said.It may be mentioned that in well-planned cities, especially in Europe, a minimum of 50 cubic feet of soil is provided for a tree’s root system to expand. However, in the city, hardly 10 cubic feet of soil is available on an average for a tree’s root system to grow and therefore, toppling of trees during squalls and thunderstorms is becoming a common phenomenon every year, according to the environmental experts.last_img read more

CM begins public meetings at Kaushambi party office

first_imgThe office was flooded with people who had gathered with their complaints and waited eagerly to personally meet the Chief Minister.“I will meet the public on three days in the week for an hour,” said the Chief Minister. “I used to conduct ‘public meetings’ but it was discontinued during the election campaign,” he added. The public meeting was, however, kept low profile and informal without any publicity. Millennium Post was the first to report on February 13 in its report ‘Power, water, primary agenda; no Janata Darbar at Delhi Secretariat’ about changed format of his previous tenure’s ‘Janata Darbar’ as party agreed to learn lessons from its failure. Also Read – Company director arrested for swindling Rs 345 croreThe Kaushambi headquarters of the party in Ghaziabad had a different scene as hundreds thronged the first Janata Darbar. The authorities, who had witnessed chaos and mismanagement during a similar programme during his 49-day tenure in Delhi last year, made elaborate security arrangements. People from various walks of life gathered since early morning as the public meeting was scheduled between 9 am to 11 am. As the district police is providing Z-plus security despite rejection from the newly elected Chief Minister, the entire area was cordoned off by putting barricades on various roads. Also Read – Man who cheated 20 women on matrimonial websites arrestedThe people who had gathered had various kinds of problems. Few had job-related issues while others had grievances regarding finance. Still others complained of delay in business due to corruption. Water and power related queries also came up in their complaints. “I, along with 50 female home guards were suspended from duty about 18 months back without giving a proper reason. They said that we would be reinstated for the next five years but the promise has not been kept. Shockingly, services of male guards were redressed while the women were barred from rejoining,” said a 29-year-old woman not wishing to be named.More than two dozen contractual workers of the Jag Pravesh Chandra Hospital met Kejriwal and told him that they had been expelled from their jobs around three months back and demanded to be reinstated.last_img read more

This 3D Printing Pen Hits 50000 Kickstarter Goal In Two Hours

first_img Growing a business sometimes requires thinking outside the box. When we heard about the pen that allows you to doodle in three dimensions, we first thought, “Huh?!?” And then we thought, “Cool!”Turns out, we weren’t alone.The Lix 3-D Pen surpassed its funding goal of 30,000 pounds – or about $50,000 — on the crowdfunding platform Kickstarter within two hours of going live. Now in its second day, the campaign has raised almost $250,000.Doodling in 3-D may be a hard concept to get your brain around. It helps if you watch the video below. The Lix pen is smaller and more nimble than the larger, bulkier first-generation 3-D printing pens. The gadget melts plastic and cools it rapidly so that the user can move his or her hand around in space and leave a line. Related: Re-Making Manufacturing in the United StatesThe device was created by a team of three inventors in Europe — Delphine Eloise Wood, Anton Suvorov, and Ismail Baran — and the company is headquartered in London. The challenge for the team was to make existing 3-D printing technology smaller. “The technology which is used in Lix Pen was developed from scratch. Our main goal was to create a professional tool which is easy to use and will have a high comfort,” the team wrote on the Kickstarter campaign. “The most difficult problem for us was to reduce the size of the mechanical parts, reposition them and let them work together.” As part of the Lix fundraise, a pledge of approximately $70 will get a customer a single 3-D printing pen. For about $135, a customer will get a single Lix 3-D printing pen and three bags of plastic — essentially, the pen’s “ink” — to use in creating works with the pen.Related: From Relic to Beacon: Brooklyn Navy Yard Gets New Life as Cutting-Edge Manufacturing Hub April 30, 2014 Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Globalcenter_img 2 min read Register Now »last_img read more