Where did your dog come from New tree of breeds may hold

first_img From the 80-kilogram Great Dane to the 1-kilogram tiny teacup poodle, there seems to be a dog for everyone. Now, the largest genetic analysis to date has figured out how those breeds came to be, which ones are really closely related, and what makes some dogs more susceptible to certain diseases.”They show that by using genetics, you can really show what was going on as [breeders] were making these breeds,” says Elinor Karlsson, a computational biologist at the University of Massachusetts Medical Center in Worcester who was not involved with the work.After dogs were initially domesticated—likely between 15,000 and 30,000 years ago—people picked the best hunters, house guards, and herding animals to be their best friends, depending on their needs. There were dogs for war and for cuddling, for fur and meat, and for being good companions. Today dogs come in 350 or so breeds, each with specific traits and behaviors. Many arose in the past 200 years. Some studies have defined the genetics of a relatively small number of breeds, but none has been comprehensive enough to show how and when most came into existence. “The whole period in between [domestication and today] has been a black box,” Karlsson says. H. G.Parker et. al. Cell Reports 19 (25 April 2017) © Elsevier Inc. The stories genes tell about dog breeds often match the breeder’s historical lore. By Elizabeth PennisiApr. 25, 2017 , 12:00 PM Where did your dog come from? New tree of breeds may hold the answer Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe A DNA comparison helped put 161 dog breeds into larger groups (various colors) based on their common ancestries. Email Click to view the privacy policy. Required fields are indicated by an asterisk (*) Sign up for our daily newsletter Get more great content like this delivered right to you! Country Elaine Ostrander and Heidi Parker, geneticists at the National Human Genome Research Institute in Bethesda, Maryland, and their colleagues spent 20 years going to dog shows, writing dog fanciers, and getting help from all corners of the world to collect DNA samples; in some cases they used already collected data. They weren’t interested in determining how and when dogs were domesticated, but how all the breeds developed. Their sample now includes 1346 dogs representing 161 breeds, or not quite half of all kinds of dogs. By comparing the differences at 150,000 spots on each dog’s genome, they built a family tree. “The scope of the analysis is very impressive, [a] tour-de-force on breed evolution,” says evolutionary biologist Robert Wayne of the University of California, Los Angeles, who was not involved with the work. Arco Images GmbH/Alamy Stock Photo Almost all the breeds fell into 23 larger groupings called clades, the team details today in Cell Reports. Although genetically defined, the clades also tended to bring together dogs with similar traits: Thus boxers, bulldogs, and Boston terriers—all bred for strength—fall into one clade; whereas herders like sheepdogs, corgis, and collies fall into another; and hunters like retrievers, spaniels, and setters fall into a third. The grouping of different breeds that share particular jobs suggests that ancient breeders likely bred dogs for specific purposes, choosing to care for those that were best at guarding or herding. Then, in the past 200 years, people subdivided those larger groups into breeds.But the data also show how some breeds helped create others, as they share DNA with multiple clades. As one of the earliest small dogs, the pug, which hailed from China, was used in Europe from the 1500s onward to shrink other breeds. Thus, pug DNA is part of many other toy and small dog genomes, Parker explains.”This is very exciting!” says Peter Savolainen, an evolutionary geneticist at the Royal Institute of Technology in Solna, Sweden, who was not involved with the work. “It shows how attractive traits from one breed [have] been bred into new breeds.”Having these clades will help veterinarians spot potential genetic problems, Parker says. For example, before vets couldn’t really understand why a genetic disease called collie eye anomaly, which can distort different parts of the eye, and shows up in collies, border collies, and Australian shepherds, also occurs in Nova Scotia duck tolling retrievers. But the genetic analysis shows that this retriever has either collie or Australian shepherd ancestors that may have passed on the defective gene. “Mixing has resulted in the sharing of specific genomic regions harboring mutations which cause disease in very different breeds,” Wayne says.Wayne and Karlsson both stress that to provide more details, the researchers should work to compare whole genomes—the entire 2.5 billion bases. And as Savolainen points out, the work “is a very good first step into the origins of all dog breeds, but half of all breeds are still missing.” Ostrander and Parker say they see this publication as a midpoint, not an endpoint. “We had reached a point where we could begin to do some of the things we wanted to do,” Ostrander explains. “By no means are we done.”last_img

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