Rooster Walk Music & Arts Festival will take place May 24-27, 2018 at Pop’s Farm in Martinsville, VA. Headlining the tenth annual event are The Wood Brothers, JJ Grey & Mofro, Robert Randolph and the Family Band, The Marcus King Band (x2), and Billy Strings. In addition to the rest of the stacked lineup which features The Jerry Douglas Band, TAUK, Sister Sparrow & The Dirty Birds, Zach Deputy, and more, the festival has announced the official Late Night Schedule.On Thursday night, The Commonheart will perform a late-night set from 10pm-12am. As the festival kicks into full gear for the weekend on Friday, JJ Grey & Mofro will close down the main stage. Then, later that evening, TAUK will perform the Lake Stage while the debut performance of “King & Strings”–a collaboration between two dynamic young musicians, Marcus King and Billy Strings band, and drummer Jeff Sipe–close down Pine Grove. On Saturday night, The Wood Brothers will close down the Main Stage, while The Marcus King Band and The Mantras party through 2am on the two other stages. Sunday night will close with The Last Yaltz, a tribute to The Band‘s The Last Waltz featuring Yarn with special guests.In addition to the above late-night shows, Rooster Walk 10 will see full performances from Colter Wall, The Dustbowl Revival, Town Mountain, Yarn, Dangermuffin, The Reverend Peyton’s Big Damn Band, The Southern Belles, Cris Jacobs, Jeff Sipe, Ron Holloway, Josh Shilling, Front Country, Victor Wainwright & The Train, The Trongone Band, Kat Wright, Wild Ponies, The Commonheart, Fireside Collective, Erin and the Wildfire, Porch 40, Kendall Street Company, Songs From The Road Band, Sanctum Sully, Jay Starling, Wallace Mullinax, Violet Bell, Half Moon, After Jack, Jason Springs Band, PHCC Jazz Band, Prosperity’s Folly, Gunchux, Juliana MacDowell, Fernandez Sisters, The Wildmans, and Aaron Crowe.To buy your tickets or learn more information about Rooster Walk Music & Arts Festival’s 10th year, visit the festival website.
Buoyed by their away victory at Nantes, Christophe Galtier’s men subdued the Kids thanks to Loic Remy’s first-half strike. Loading… Promoted Content6 Incredibly Strange Facts About Hurricanes8 Fascinating Facts About CoffeeThe Very Last Bitcoin Will Be Mined Around 2140. Read More7 Reasons Why You Aren’t Getting The Tasks DoneCouples Who Celebrated Their Union In A Unique, Unforgettable WayA Soviet Shot Put Thrower’s Record Hasn’t Been Beaten To This DayWhich Country Is The Most Romantic In The World?7 Of The Wealthiest Universities In The World6 Major TV Characters We Were Relieved To See Leaving The Show10 Phones That Can Work For Weeks Without Recharging7 Universities Where Getting An Education Costs A Hefty Penny2020 Tattoo Trends: Here’s What You’ll See This Year Victor Osimhen’s Lille were 1-0 better than Olympique Lyon in Sunday’s night Ligue 1 encounter at Stade Pierre-Mauroy.Advertisement Read Also: La Liga: Real Madrid give away top spotParis Saint-Germain’s game at Strasbourg on Saturday was postponed due to fears over the coronavirus outbreak.The decision was made after a number of people tested positive for COVID-19 in the Haut-Rhin region, which neighbours the Bas-Rhin region where Strasbourg is located.It was the first Ligue 1 match to be called off because of the virus, which has infected 1,126 people in France and caused 19 deaths.FacebookTwitterWhatsAppEmail分享 Left unmarked in Lyon’s goal area, Remy fired past goalkeeper Anthony Lopes after receiving a clever pass from Jonathan Bamba.In the process, the 33-year-old becomes the player who has scored the most against Lyon in the 21st century with seven goals.Lille could have gone two goals up in the second half but his effort kissed the woodwork.The visitors could have snatched a late minute equliser but substitute Bertrand Traore shot over the bar despite making mincemeat of two Lille defenders.Victor Osimhen was in action for the entire duration of the game while Reinildo Mandava replaced Bamba in the 90th minute.For Rudi Garcia’s men, on-loan Villarreal forward Karl Ekambi and Maxwel Cornet were on parade from start to finish.Thanks to this triumph, Lille sit in fourth position with 49 points from 28 games – 19 points below leaders Paris Saint-Germain.“We will continue our journey, our path,” said Lille coach Christophe Galtier. “It (the last part of the season) is a sprint and every match is going to be a fight.”
It would be a stretch to say Russia deserved their win, with 26 per cent possession and only six attempts at goal compared with Spain’s 25, but they had a plan, stuck to it, and fought to the bitter end.A 4-3 victory on penalties, after the sides were locked at 1-1 at the end of extra time, sends the hosts through to their first World Cup quarter-final since 1970.Spain’s dominance will do nothing to ease the disappointment following what can now be judged as a truly farcical World Cup campaign.Julen Lopetegui, the coach fired two days before Spain’s opening match, and Luis Rubiales, the Spanish Football Federation president who fired him, will be circled as the key offenders.Spain goalkeeper David de Gea made just one save at the World Cup © AFP / Juan MabromataBut Fernando Hierro, Lopetegui’s replacement, and David de Gea, who endured a torrid tournament in goal, will take their share of the blame too.It was a pity that the last match of Andres Iniesta, who later confirmed his international retirement, in the end became little more than a footnote.“What started badly, ended badly,” wrote Marca. “All the problems began with the dismissal of Lopetegui and then continued with a team lacking in form and ideas.”Rubiales was quick to make clear he felt no remorse for sacking Lopetegui, who was clumsy in the way he handled his pending move to Real Madrid, but seemingly dismissed because of hurt, personal pride.“Today there is pain, as we have been eliminated,” Rubiales said. “But you can be calm when you know you have acted with responsibility, conviction and values. You cannot later look in hindsight because of a result on the pitch.”– Positive start –Many would argue it was clear at the time that changing the coach two days before Spain’s opening game was unlikely to benefit the team.With Hierro in place, however, there were positive signs against Portugal, when Cristiano Ronaldo’s free-kick overshadowed an assured Spain performance in a 3-3 draw.Coach Fernando Hierro comforts Sergio Ramos after Spain lost their penalty shootout against Russia in the last 16 of the World Cup © AFP / Juan MabromataBut defensive errors and tactical rigidity soon came to the fore as poor displays followed against Iran, Morocco and Russia.Sergio Ramos and Gerard Pique were both guilty, the latter because of a handball that gave Russia their equaliser, but De Gea left as the principal villain.Against Portugal, he allowed Ronaldo’s shot to slip through his hands. Against Russia, Igor Akinfeev starred in the shootout while he failed to save at least two spot-kicks he might have kept out.By the end, De Gea had made only one save all tournament.As the late stand-in, Hierro may be spared such stinging criticism but he dropped Iniesta and Dani Carvajal against Russia in Moscow, only to bring both on as substitutes, and then replaced Diego Costa with Iago Aspas, who arguably should have been on from the start.Rubiales sidestepped questions about who will be the coach long-term but Hierro is surely unlikely to continue.Whoever it is, they will now face the same two-pronged brief that Lopetegui was tasked with two years ago: to restore confidence and blood the younger generation.Of the starting eleven against Russia, only Marco Asensio will be younger than 30 by the time the next World Cup comes around. Pique, Ramos, David Silva, Costa and Sergio Busquets will be 33 or older.It means those left from the triple triumph of Euro 2008, the 2010 World Cup and Euro 2012 will either be gone or down to the last few and that could pave the way for an evolution of style too.A debate has emerged during this tournament around Spain’s possession game and it might be that a new manager decides to update the old, winning formula.But for all the talk of tactics and generational change, Spain’s 2018 World Cup will be remembered for a simple act of self-sabotage. This was the team that was ready and then on the eve of the tournament, sacked their coach.0Shares0000(Visited 1 times, 1 visits today) 0Shares0000Spain’s Koke reacts after missing a spot-kick during the penalty shoot-out against Russia in the World Cup last 16 © AFP / Francisco LEONGSAINT PETERSBURG, Russian Federation, Jul 2 – Spain’s World Cup roller-coaster ride finally ground to a halt on Sunday and the finger-pointing began after their third consecutive failure at a major tournament.Following humiliation at the hands of the Netherlands in 2014 and a limp defeat to Italy at Euro 2016, this was perhaps the most galling exit of all, given it came at the hands of Russia, ranked 70th in the world, just above Macedonia and El Salvador.
Jun 7 2018Researchers at the University of Zurich have discovered the identity of the stem-cell niche of the colon. The niche comprises special cells that activate the stem cells of the adjacent intestinal epithelium and are responsible for its continuous renewal. Without the activation signal, the epithelium perishes. If it’s constantly activated, early stages of cancer develop. The discovery helps to improve our understanding of intestinal cancer and inflammation.The human intestine constantly renews itself. Alone in the colon – the last 1.5 meters of the gastrointestinal tract – 10 billion epithelial cells are replaced each day. The intestinal epithelium is the layer of cells that forms the lining of both the small and large intestine and is responsible for absorbing nutrients. The regeneration process is driven by stem cells that are found in small folds of the epithelium (crypts), where they are in contact with other cells that produce the signals needed to drive regeneration. The key activating signal that sustains the stem cells is called “Wnt”.Colon stem cells perish without signalingA group of UZH researchers, including Konrad Basler from the Institute of Molecular Life Sciences, have now discovered the cells responsible for providing the activating signal to the stem cells. These so-called Gli1-positive cells surround the crypts in the epithelium and thereby form the stem-cell niche. The scientists performed studies in mice to demonstrate that these cells play an essential role in forming and repairing the intestinal epithelium. “If the Gli1-positive cells are eliminated or unable to secrete Wnt proteins, the activation signal is lost. Consequently the colon’s stem cells as well as the epithelium will perish, and the organism dies,” says Basler.Related StoriesSlug serves as ‘command central’ for determining breast stem cell healthAbcam Acquire Off-The-Shelf Diploid Library of Over 2,800 Knockout Cell LinesNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’Long-term constant activation leads to colon cancerJust how critical a well-balanced regulation of the intestinal epithelium is also becomes evident when stem cells are driven to constantly divide. If Wnt signaling is stimulated excessively, the stem cells divide in an uncontrolled manner. “Mice with mutations in the Wnt signaling pathways develop polyps, from which colon cancer later develops,” adds the molecular biologist. This is also the case for humans.Niche cells are also responsible for tissue repairIn further tests, the researchers examined the behavior of the cells in the stem-cell niche in response to inflammation of the colon. In this situation, many more epithelial cells are lost than in healthy animals. The need for new cells is therefore greater, since the tissue not only has to be maintained but also repaired. The researchers observed that the amount of Gli1-positive cells increased significantly in response to an inflamed colon. “The cells we’ve discovered are thus not only essential for healthy organisms, but are also essential when it comes to repairing a damaged intestinal epithelium,” says Basler. The discovery and description of the colon’s stem-cell niche therefore has relevance for a whole string of intestinal diseases, from inflammation to cancer. Source:http://www.media.uzh.ch/en/Press-Releases/2018/colon-stem-cell-niche.html